The story of how the secret of life has been examined through the prism of the most complex organism known - the human body. It begins with attempts to save the lives of gladiators in Ancient Rome, unfolds with the macabre work and near-perfect drawings of Leonardo in the Renaissance, through the idea of the 'life force' of electricity, to the microscopic world of the cell. It reveals how a moral crisis unleashed by work on the nuclear bomb helped trigger a great breakthrough in biology - understanding the structure and workings of DNA.

A Winning Design clarifies what makes a mammal different from reptiles and birds. No, it isn't egg-laying: both the platypus and the echidna are egg-laying mammals; it's their ability to adapt. And it's this adaptability that becomes the crux of the remainder of the series. From the tiniest bat to the massive blue whale, all mammals share the ability to nurture their young on milk and regulate their own temperatures.

Are the wealthy just born in the right place at the right time? Are the poor victims of a system designed to keep them down? Or do physics and biology determine who is rich and who is poor? Throughout history, distribution of wealth is governed by hidden forces: DNA, environmental stress, patterns of human migration and even the laws of thermodynamics! Nature seems to demand winners and losers in life. But does this mean greed is king, and the rich can take what they want? Or is cooperation – between microorganisms, monkeys, and humans – more essential to survival of a species?

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

In August 2014, ISIS militants raided a Yazidi village in Syria, kidnapping thousands of men, women and children. Hundreds of the kidnapped men were killed or forced to convert to Islam; the women and children were sold as sex slaves or to marry ISIS fighters. Many were raped or became victims of other forms of sexual violence. Escaping ISIS depicts 34 of those captured by militants last year — mostly women and young children — reuniting with their families as they escape to freedom". Some victims were brought to freedom through underground networks, guides inside ISIS and resistance fighters. Women contacted the resistance fighters, begging for rescue; some said the alternative is committing suicide. Many escapees walk for several days with little food and water, often barefoot, risking getting recaptured and killed. One resistance fighter was shot in the back of the head in ISIS territory after they found out that he was working against them. The documentary shows parts of this treacherous journey to freedom.

Odds are excellent that extraterrestrial life exists. So why haven’t we found aliens out in the galaxy? Are we looking in the wrong places? New research shows we should look closer to home, even inside our bodies. It turns out that a lot of our DNA is from a mysterious, nonhuman source. Theoretically, alien microbial life can make the journey to Earth from distant worlds, and scientists are finding some unearthly microbes in our upper atmosphere. Could it be from outer space? Could we be part alien? It’s even possible alien life is already here as digital life forms, hiding inside our technology.